Musclez & lacertez bene one selfe þing, Bot þe muscle is said to þe fourme of mouse & lacert to þe fourme of a lizard. [Guy de Chauliac, "Grande Chirurgie," c. 1425]Hence muscular and mousy are relatives, and a Middle English word for "muscular" was lacertous, "lizardy." Figurative sense of "force, violence, threat of violence" is 1930, American English. Muscle car "hot rod" is from 1969.