de-, 向下，强调。-stin, 站，站立，词源同stand, institute. 即下一个立足点，目的的。
英文词源
destination (n.)
1590s, "act of appointing," from Latin destinationem (nominative destinatio) "purpose, design," from past participle stem of destinare "determine, appoint, choose, make firm or fast," from de- "completely, formally" (see de-) + -stinare (related to stare "to stand") from PIE *ste-no-, from root *sta- "to stand" (see stet). Modern sense (1787) is from place of destination, where one is "destined" to go.
实用例句
1. His destination was Chobham Common, a long way from his Cotswold home.
他的目的地是乔伯姆公地，那里和他在科茨沃尔德的家离得很远。
来自柯林斯例句
2. St Lucia is still mercifully undeveloped as a tourist destination.
作为一个旅游目的地，圣卢西亚所幸还未被开发。
来自柯林斯例句
3. You can check your baggage right through to its final destination.
你可以把行李直接托运到终点。
来自柯林斯例句
4. Life can be likened to a journey with an unknown destination.
生活可以被比作一次不知目的的旅行.
来自《简明英汉词典》
5. To find out, make Christchurch your next vacation destination.