Background and Objective The goals of this study were to label the antisense oligodeoxynucleotides(ASODN) indirectly by Chloramine T method and Iodogen method, then to discuss the labeling yields、radiochemical purity、specific activity and stability in different conditions.
方法:1、氯胺T法125I直接标记乙酰双半胱氨酸(EC),证明其可行性。
HCl(7-amino-3-chloromethyl-3-cephem-4-carboxylic acid p-methoxy-benzylester hydrochloride) was prepared using imidechloride process in one step from GCLE(7-phenylacetamide-3-chloromethyl-3-cephem-4-carboxylic acid p-methoxybenzyl es-ter) in a yield of 91.
以GCLE(7-苯乙酰氨基-3-氯甲基-3-头孢环-4-羧酸对甲氧苄酯)为原料,采用偕氯亚胺法一步合成ACLE。
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