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Application of supercritical anti-solvent technology in production of pharmaceutical microparticles;

超临界抗溶剂技术在药物微粒化领域的研究进展

Two common methods of supercritical fluids recrystallization,rapid expansion of supercritical solution and supercritical anti-solvent crystallization are introduced.

总结了超细药物微粒的常规制备方法,对超临界重结晶技术的两种常用方法,即超临界流体快速膨胀法和抗溶剂法进行了介绍,阐述了它们的应用进展情况,回顾了两种方法在国内中药药材领域的研究情况。

7) on the quality of soft-serve ice cream was studied by testing the following physical properties: the viscosity and emulsification-stabilization of the plasma, the rigidity, the overrun and the resistant-melted of soft-serve ice cream as well as observing its micro morphological tissue using a microscope with magnification 40.

结果表明,单甘酯对膨化率、硬度、抗溶性有比较理想的促进作用,综合效果最好,其理想添加量为0。

The use of supercritical antisolvent for the formation of fine particles is developed recently.

介绍了超临界抗溶剂的原理 ,分析了工艺条件对粒子尺寸和尺寸分布的影响 ,着重说明了其在药物方面的应用。

On the background of the separation and purification processes of high-value protein products, supercritical antisolvent (SAS) precipitation technology was integrated with conventional precipitation of organic solvent, thus a new separation process of precipitation of proteins in mixed solvent using compressed carbon dioxide was formed.

以高附加值蛋白质的分离、纯化为背景，将超临界抗溶剂(SAS)沉淀技术与传统的有机溶剂沉淀法相结合，形成了用加压CO_2从混合溶剂中沉淀蛋白质的新型分离方法。