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Recent developments and approaches for anti-HIV chemical drugs in clinical trials were re- viewed and analyzed in this manuscript,including new agents of entry inhibitors,reverse transcriptase inhibitors, integrase inhibitors,protease inhibitors,maturation inhibitors,zinc finger inhibitors,and so forth.

综述和分析了目前国内外正在进行的抗HIV化学药物临床试验的进展情况,这些药物包括进入抑制剂、逆转录酶抑制剂、整合酶抑制剂、蛋白酶抑制剂、成熟抑制剂、锌指抑制剂等。

RESULTS There were tremendous progresses in the anti-HIV-1 drugs,including the novel fusion inhibitors,the classical protease inhibitors,reverse transcriptase inhibitors.

结果发现抗艾滋病药物在近年来有突破性进展,除了传统的蛋白酶抑制剂,逆转录酶抑制剂外,最新发展的融合抑制剂类药物已上市,并且还有很多具有新型作用机制的化合物以及具有抗H IV-1活性的先导天然化合物正处于研究阶段。

Anti-HIV activities of HIV-1 reverse transcriptase inhibitor racemic 11-demethyl-calanolide A;

HIV-1逆转录酶抑制剂消旋11-去甲胡桐素A的抗HIV-1活性研究

QSAR studies on HIV-1 reverse transcriptase inhibitors 2-Amino-6-arylsulfonybenzonitrile and its analoges;

HIV-1逆转录酶抑制剂2-氨基6-苯磺酰基苄腈及其类似物活性OSAR研究

AIM To study the effect of inhibition of telomerase activity by reverse transcriptase inhibitors (AZT) on ovarian cancer cells in vitro.

目的　研究逆转录酶抑制剂 (AZT)对卵巢肿瘤细胞端粒酶活性的影响 。

RT-PCR kit with different reverse transcriptase affected detecting result of COX-2 mRNA expressoin;

不同逆转录酶的RT-PCR反应体系影响COX-2 mRNA表达的检测结果

Progress in HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs);

HIV非核苷类逆转录酶抑制剂研究进展

Expression of telomerase reverse transcriptase and its significance in human fetal lung development;

人胎肺发育不同阶段端粒酶逆转录酶的表达及意义

Studies on a Novel Non-Nucleoside Reverse Transcriptase Inhibitor--Nevirapine;

新型逆转录酶抑制剂Nevirapine的研制

Studies on the Screening Method of HIV-1 Reverse Transcriptase Inhibitors;

HIV-1逆转录酶抑制剂筛选方法的研究

Design, Synthesis and Evaluation of Benzimidazole Derivatives as a Novel Class of HIV Non-nucleoside Reverse Transcriptase Inhibitors (NNRTIs);

新型HIV非核苷类逆转录酶抑制剂（NNRTIs）

Designing and Screening of non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors

非核苷类逆转录酶抑制剂的设计与筛选

Advances in the development of new generation of HIV-1 non-nucleoside reverse transcriptase inhibitors

新一代非核苷类HIV-1逆转录酶抑制剂研究进展

Combinations of a protease inhibitor with two nucleoside reverse transcriptase inhibitors are currently recommended for postexposure prophylaxis of relatively high-risk exposures.

对相对高危暴露，目前推荐用一个蛋白酶抑制剂结合两个逆转录酶抑制剂作暴露后预防治疗。

Studies on the Synthesis of HIV-I Reverse Transcriptase Inhibitor Delavirvine Mesylate;

HIV-1逆转录酶抑制剂甲磺酸地拉夫定的合成研究

Effects of Radiosensitization of Reverse Transcriptase Inhibitor on Human Malignant Glioma Cells U251;

逆转录酶抑制剂对人脑胶质瘤U251细胞放射增敏作用的实验研究

HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Design, Synthesis and Antiviral Evaluation of Thiadiazole and Isothiazolone Derivatives;

硫唑类HIV-1非核苷逆转录酶抑制剂的设计、合成及活性研究

The HIV-1 Pharmacological Models Which Resist to Non-nucleoside Reverse-transcriptase Inhibitors;

对非核苷类逆转录酶抑制剂耐药型HIV-1药理模型的建立

Design, Synthesis and Bioactivity Evaluation of Novel Substitutde 1, 2, 4-Triazole Derivatives as HIV-1 NNRTIs

取代三唑类HIV-1非核苷类逆转录酶抑制剂的设计、合成及活性研究

Design, Synthesis and Biological Evaluation of Benzosultams as Novel HIV-1 Reverse Transcriptase Inhibitors

苯并磺内酰胺类HIV-1逆转录酶抑制剂的设计、合成及活性研究

Experimental Study of the Effect of Reverse Transcriptase Inhibitor AZT in Rat C6 Glioma Cells in Vitro

逆转录酶抑制剂AZT对大鼠C6胶质瘤细胞作用的体外研究

Review of the study of structure modification of HIV NRTIs on the principles of bioisosterism

基于生物电子等排原理的核苷类HIV-1逆转录酶抑制剂研究进展

Establishment of pharmacological evaluation system for non-nucleoside reverse-transcriptase inhibitors resistant HIV-1

非核苷类逆转录酶抑制剂耐药型HIV-1药理评价体系的建立

Recent advance on characteristics of HIV-1 non-nucleoside reverse transcriptase inhibitors binding modes and design strategies to overcome drug-resistance

新型HIV-1非核苷类逆转录酶抑制剂的结合模式特征与抗耐药抑制剂设计研究进展

Design and Synthesis of the Pyrazolothiadiazines and Thienothiadiazines as HIV Reverse Transcriptase Inhibitors;

吡唑并噻二嗪及噻吩并噻二嗪非核苷类HIV逆转录酶抑制剂的设计、合成和活性研究

Anti-human immunodeficiency virus type 1 activity of two new nonnucleoside reverse transcriptase inhibitors in combination with other 3 antiretroviral agents in vitro

两种非核苷类逆转录酶抑制剂与已上市药物联合应用的体外抗HIV活性研究